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Evidence is increasing that addiction without exception is related to issues with the brain's reward center, especially the mesolimbic system. This the main problem regulates reward responses in acquiring food and sex, plus nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both when they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to shed weight can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people that go through it you need to err on the side of caution and let the FDA do its job and demand some investigation be done so the public is aware of the side effects and risks of the medications before we drive them. Keep in mind that drug companies have been in business to generate income and that they would say everything to keep people on the medications. Researchers found that participants using this drug for a year, dropped a few pounds within 4 weeks and have kept the load off during the entire 56 weeks with the study. Contrave is really a combination with the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs which can be made up of multiple active ingredient, that might make them more efficient and safer. Combo-pilling could be the newest fad or in addition to this the newest to come under scrutiny and therefore it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular is the fact that as of right now there aren't any long term prescription weight loss supplements that have been authorized by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be approved by the FDA. Seizures really are a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug can also raise blood pressure level and heartrate, and mustn't be used in people with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure level and heartrate and must not used in patients with uncontrolled high hypertension, as well as by anyone with heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients using a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients towards the increased probability of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for quitting smoking. BioCorRx, Inc.'s naltrexone implant is not any bigger than a thumb and it is inserted beneath the patient's skin through a 30-minute, noninvasive outpatient procedure created by a medical expert. The implant is administered included in BioCorRx, Inc.'s Start Fresh Program that is distributed in numerous states by independent rehabilitation facilities.